Defense Advanced Research Projects Agency (DARPA)

Defense Advanced Research Projects Agency (DARPA)

Close: Apr 1, 2026

Modern computation involving AI training and inference has significant energy requirements. These demands impact our ability to boost warfighter performance at the edge, where restricted energy capacity affects operational longevity, compute capability, and data transfer latency. O-CIRCUIT envisions unlocking operational advantages by developing unconventional biological processing units (BPUs) for edge learning and inference with minimal power draw (mWh/day). O-CIRCUIT also envisions extending these BPUs to sensing physical stimuli and outputting instructions, such as directing drone navigation. See attached file.

Defense Advanced Research Projects Agency (DARPA)

Close: Apr 11, 2026

The vital (virtual-integrated twin for autonomous lifesaving) program aims to develop continuously updating computational models of the cardiovascular system that integrate patient data with biological physics to predict outcomes in real time. The vision of vital is to enable future providers and clinicians to assess treatment options for acute and chronic pathologies. Vital plans to establish a foundation for causal, prediction-driven decision support using high- fidelity (hf) digital twins that explicitly represent the physical, biochemical, and anatomical dynamics governing cardiovascular physiology. Hf models will be developed and benchmarked as the baseline predictive reference across static, chronic, and acute regimes. For each regime, the program intends to quantify computational speed, forecast horizon, predictive accuracy, uncertainty bounds, data requirements, sensitivity to parameter estimation, segmentation error, and measurement sparsity. A core program outcome is a rigorous characterization of hf model capability limits, providing evidence-based guidance on when hf models are suitable as foundational technology and where fundamental limitations remain. See attached file.

Defense Advanced Research Projects Agency (DARPA)

Close: May 15, 2026

Bordeaux is a 36-month program organized into two phases. Security Startup Period is 3 months, Phase 1 is 18 months (Base), and Phase 2 (Option) is 18 months. This PS is soliciting proposals for both phases. Additionally, this PS is requesting proposers submit an estimate for a 12 month Transition Phase. The Transition Phase is not being solicited by this PS and only serves as a rough estimate in case the need for a Transition Phase arises at the end of the program.