Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

Description: The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office is issuing a Disruption Opportunity for innovative basic or applied research concepts in targeted neuroplasticity under the Program Announcement for Disruptioneering, DARPA-PA-25-07 Amendment 1. Awards will be made as Other Transaction Prototype Agreements, with a total award value limited to $2,000,000 per award, including government funding and any required or proposed performer cost share. The SHINE effort seeks non-invasive technologies that selectively target plasticity-inducing methods to defined neural substrates and affected pathways, with offers due October 9, 2026, at 4:00 p.m. EDT.