The National Institute of Allergy and Infectious Diseases (NIAID) is soliciting applications to support the Childhood Asthma in Urban Settings Clinical Research Network (CAUSE), a multi-site clinical research network focused on prevention and treatment of asthma in economically disadvantaged pediatric populations. The network will support multi-site clinical studies and trials and will use systems-biology approaches to identify disease endotypes; the notice lists estimated funding of $8,380,000 and a budget estimate range of $5,000,000–$10,000,000. Full solicitation documentation and response instructions are available on Grants.gov at the listed posting.