AAV9 Viral Vector Manufacture Support

Description: Leidos Biomedical Research, Inc. seeks a manufacturer for clinical-grade AAV9-MMAB material for a gene-therapy product for cblB-type methylmalonic acidemia caused by MMAB variants. The scope includes process transfer, upstream and downstream production, analytical method validation, fill-finish, release testing, stability-program establishment, and cGMP documentation for at least 1×10^16 genome copies of clinical material. The posting identifies solicitation S25-102 under NCI OA Contract 75N91019D00024 – NCI-FFRDC and states that proposals are due Wednesday, September 23, 2026 at 1:00 PM ET.