National Mediation Board

National Mediation Board

Close: Jul 10, 2026

TA1: Measure & Diagnose: TA1 focuses on development of validated, in-home systems for objective measurement of sleep-relevant physiology, diagnosis of poor sleep centered on insomnia, and mechanistic classification of poor sleep. TA1 efforts are expected to translate clinically meaningful sleep measurement into home settings and generate outputs that support screening, diagnosis, and future treatment matching. TA2: Control & Treat: TA2 focuses on development of noninvasive, closed-loop systems that adapt intervention to the user’s sleep state and physiology in real time to improve sleep quality and treat insomnia. TA2 efforts are expected to sense relevant physiological features during sleep, personalize intervention across the night, and improve clinically meaningful outcomes. See attached file.

National Mediation Board

Close: Feb 26, 2027

TA1: Defining and generating precursor tissue for any brain region, including identification of all cellular and extracellular components via omics and histology, and protocols for generating human iPSC-derived precursor cells. TA1 Milestones: 1. Detail specifications of target tissue via characterizing natural precursor tissue (all cell types, density, spatial organization, non-cellular components). 2. Establish protocols for generating all the relevant precursor cell types. 3. Elaborate a detailed tissue generation method. 4. Generate prototype precursor tissue with demonstrated metrics of equivalence to natural precursor tissue. See attached file.

National Mediation Board

Close: Aug 14, 2026

TA1 Intracortical Device(s): Creation of minimally invasive devices that can interface with key auditory regions through recording and stimulation, without requiring surgical access through the skull, and are suitable for chronic use. TA2 Dynamic Sound Modulator: Development of an external, hearing-aid-like hub that wirelessly powers and bi-directionally communicates with the brain interface, adjusting sound in real time based on algorithmic control informed by neural signals. TA3 Auditory Read & Write Algorithms: Design and deployment of algorithms within a processing unit that decode what the listener is trying to hear to determine how to deliver or supplement sound so that speech becomes clearer, more complete and understanding speech is less strenuous. This will be accomplished either by enhancing the TA2 device with code to control audio input gain or by transmitting restorative code to stimulate the brain through the TA1 device. See attached file.