Aug 7, 2026
Closes
Oct 19, 2026
Protein ENGineering (PENG)
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The Protein ENGineering (PENG) program seeks to transition proteome engineering from isolated, bespoke tools into a universal, software-defined discipline. It will establish an integrated platform with modular targeting, generalizable effector chemistries, and multiplexed control systems.