Description: The Health Science Futures (HSF) ISO seeks solution summaries and proposals for projects within ARPA-H's mission office, which supports cutting-edge, often disease-agnostic research with potential for translational real-world change. Applicants submit solution summaries through ARPA-H's portal and proposals through its proposal portal. The active solicitation accepts submissions through March 5, 2029, and ARPA-H says it does not provide research grants, instead relying primarily on alternative mechanisms such as Other Transactions and cooperative agreements.
Federal · MD, US
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FederalMD
Posted
Jun 6, 2025
Mar 6, 2029
Provide solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness.
Posted
Mar 14, 2024
Mar 6, 2029
The Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ARPA-H-SOL-24-106) seeks solutions to improve healthspan and health outcomes before disease onset, including population-level prevention programs, novel early-detection methods, prophylactic interventions, and system-level delivery innovations. The solicitation requires submission of a Solution Summary via ARPA‑H’s Solutions portal (proposers must receive written feedback on summaries before submitting full proposals) and provides submission instructions and amendment updates on the official posting. This is a solicitation notice (not a cooperative-agreement grant) with an updated offers-due date shown on the official posting.
Posted
Sep 24, 2026
Dec 16, 2026
TA1: Imaging Core: The goal of TA1 is to establish the feasibility of generating and measuring quantum-derived imaging contrast using entangled 511 keV photons, positronium-sensitive interactions, and decoherence-aware imaging architectures in controlled phantom and benchtop systems. A competitive submission should specify the mechanism(s) for producing entangled 511 keV photon pairs and the rationale for achieving the entanglement yield and usable flux in the Program Metrics [see Table 1] while balancing flux against imaging dose. It should describe how quantum correlations will be measured and verified across scattering media, and detail the phantoms, materials, detectors, timing, and filtering being employed to deliver the required signal-to-background and localization performance. Proposers should identify the candidate quantum-derived observables and biologically meaningful phantom states (e.g., pyruvate/lactate-linked microenvironments) used to demonstrate reproducible contrast separation, define the data products delivered to TA2, and articulate primary risks with mitigations. See attached file.
FederalMD
Posted
Mar 14, 2024
Mar 6, 2029
Office-wide innovative solutions opening for proactive health office.
