Institutional Biosafety Committee Minutes
The meeting addressed several agenda items, including the conflict of interest recusal for Dr. Shilpa S. Dhar regarding project RM00007811-RN00_AM5. Reports were presented by the Manager of Environmental Health & Safety and the Director of Environmental Health & Safety Administration, both stating nothing to report. The agenda included reviews of new protocols. For BSL-2 New Protocols, several protocols were approved with contingencies: RM00008602-RN00 concerning COVID Spike mRNA mix in animals, RM00004922-RN01 involving lung cancer promotion mechanisms via COPD condition, RM00004887-RN01 for a clinical protocol involving engineered NK cells in astrocytoma patients, RM00008586-RN00 involving melanoma cell lines and fecal microbiota transplantation, RM00008605-RN00 concerning CAR-T cell therapy for B-cell lymphoma, RM00001309-RN02 studying lung tissue regeneration, RM00008580-RN00 regarding an advanced melanoma study using a modified HSV1 virus, RM00001523-RN02 involving the functions of mutated mTOR, RM00008558-RN00 concerning efficacy in multiple myeloma, RM00007811-RN00_AM5 involving amendments to a protocol with lentiviral and non-viral vectors targeting gastric adenocarcinoma, RM00000781-RN02_AM8 adding an adenovirus backbone for a study on aging and Alzheimer's research, RM00006199-RN00_AM1 updating personnel and IACUC protocol numbers, RM00007111-RN00_AM7 with minor edits to an experimental plan, RM00002650-RN01_AM11 adding elements for transfer via MTA, RM00005849-RN00_AM60 updating an IACUC protocol number, RM00006297-RN00_AM8 updating an IACUC protocol number related to HIV-1 variants, RM00006717-RN00_AM9 adding retroviral backbones and HEK293 derived cell lines, RM00008452-RN00_AM1 adding a lentiviral plasmid, RM00000627-RN02_AM16 adding an objective related to aging and Alzheimer's research, RM00004137-RN01_AM2 adding agents for in vivo administration, RM00000599-RN02_AM10 involving extensive vector list consolidation, RM00006480-RN00_AM7 adding an adenovirus backbone and utilizing the sleeping beauty system, RM00000187-RN02_AM8 updating vector information, RM00004261-RN01_AM2 updating IACUC protocol and grant funding details, RM00000378-RN02_AM9 adding a new IACUC protocol, RM00000505-RN02_AM5 involving updates to various vectors and cell lines, RM00000201-RN02_AM2 updating an IACUC protocol number, and RM00003599-RN01_AM5 concerning the removal of human cell lines. Section 8 addressed Administrative Modifications for protocol RM00007111-RN00_AM8.