JPEO-CBRND EB New Approach Methods (NAMs) (RFI)

Information on new approach methodologies for CBRN use cases areas of interest include and are not limited to: recapitulation of in-vivo CBRN threat exposure, disease states and pathologies; NAM approaches to support or replace key nonclinical toxicology, pharmacology or efficacy studies used to support MCM development; NAM approaches that inform human estimated dose; use of artificial intelligence and machine learning capabilities to augment or improve NAMs, accelerate toxicology studies, or other in-vivo studies.